How do pathogens adapt to their hosts and what is the evolutionary basis of this adaptation?

About Us

The Ghedin Lab is a member of the Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH in Bethesda, MD. Our research is focused on defining genomic characteristics of human pathogens.  We use a multidisciplinary approach, drawing on genomics, molecular virology, parasitology, and computational biology to unravel the complex relationships between pathogens and their hosts.

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Integrating multiple omics methodologies to gain a wholistic, systems-level understanding of complex host responses to infection and vaccination.

Our research is harnessing the power of omics to gain deeper resolution of the host environment.

Seeking to understand the complex interactions between Brugia Malayi (a filarial nematode) and its endosymbiotic bacterium, Wolbachia.

Our studies address key questions on the reciprocal cues required in the co-dependency between the worm and the bacteria.

Investigating drivers and outcomes of respiratory virus evolution.

We are generating novel insights into the evolutionary dynamics of respiratory pathogens.

Characterizing microbial ecology in upper airways and chronic wounds.

Our research provides a systems-level landscape of microbial communities, and defines how these communities impact infection outcomes.

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Lab News

Yearlong infection spawned a striking mutation beyond SARS-CoV-2’s spike protein.

A cancer survivor had the longest documented COVID-19 infection. Our lab helped investigate this novel case and was recently interviewed by JENNIFER COUZIN-FRANKEL at Science.org. ...
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RyeAnne Ricker awarded NSF Fellowship

Congrats to RyeAnne Ricker, a PhD candidate in the Ghedin Lab, who was awarded an NSF Fellowship in August 2021. From the GRFP website: The ...
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High Virus Count in the Lungs Drives COVID-19 Deaths – Research

Collaboration Research Press Release – Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Aug ...
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