Rita Afriyie Boateng, PhD

Position: Post-doctoral visiting IRTA (APTI)

Education: PhD, Rhodes University, South Africa
Post-doctoral Fellow, Noguchi Memorial Institute for Medical Research

Rita employs a hybrid approach, combining pre-clinical testing and computational analyses, to discover anti-filarial drugs that target molecular processes and host-parasite interactions.

Rita also utilizes protein structural information to determine the effects of SARS-CoV-2 spike mutations.

Career Goal: Rita aspires to establish a prominent presence in the public health pharmaceutical research industry, contributing to the global healthcare landscape by conducting research and initiatives on drug development. Her primary objective is to create a dedicated channel for the discovery of drugs targeting infectious diseases and Neglected Tropical Diseases (NTDs).

Selected Publications

Boateng, R.A., Myers-Hansen, J.L.., Dolling, N.N.O., Mensah, B.A., Brodsky, E., Mazumder, M., Ghansah, A. Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study. Molecules 2023, 28, 145. https://doi.org/10.3390/molecules28010145.

Sheik Amamuddy#, O., Boateng, R. A#., Barozi, V., Nyamai, D. W., Tastan Bishop, Ö. Novel dynamic residue network analysis approaches to study homodimeric allosteric modulation in SARS-CoV-2 Mpro and in its evolutionary mutations. Comput. Struct. Biotechnol. J. (2021). DOI: 10.1016/j.csbj.2021.11.016.

Boateng, R. A., Tastan Bishop, Ö., and Musyoka, T. M. Characterisation of plasmodial transketolases and identification of potential inhibitors: an in-silico study. Malar. J. 19, 442 (2020). DOI: 10.1186/s12936-020-03512-1

Sheik Amamuddy, O., Musyoka, T. M., Boateng, R. A., Zabo, S., and Tastan Bishop, Ö. Determining the unbinding events and conserved motions associated with the pyrazinamide release due to resistance mutations of Mycobacterium tuberculosis pyrazinamidase. Comput. Struct. Biotechnol. J. 18, 1103–1120 (2020). DOI: 10.1016/j.csbj.2020.05.009

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