Virus evolution, transmission, and pathogenesis in populations at risk
We study the evolution of respiratory viruses of prominent public health concern. During the course of infection, viruses adapt to the host environment. These adaptations may impact virus transmission and disease severity. Our goal is to characterize virus diversity and quantify the impact of host factors on diversity, transmission, and pathogenesis. We can also use genomic epidemiology to track the emergence of novel variants and identify transmission clusters.